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Senescence: Cells, ageing and cancer.



The following appears in the last number of NATURE. It could be of interest to the list.

 

 

This week in Nature four groups show, with striking in vivo evidence, that oncogene-induced cellular senescence represents a safety mechanism to suppress tumor progression. The identification of senescence as a defining feature of premalignant tumors could prove valuable in the diagnosis and prognosis of cancer. This web focus brings together key publications on senescence and cancer including primary research papers, News & Views and a review article.

Is growing old a good thing? As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Four papers in Nature show that, as previously suggested by in vitro studies, oncogene-induced cellular senescence represents a safety mechanism to suppress tumour progression in vivo. Cellular senescence also plays a key role in ageing. In this web focus, Nature brings together articles on senescence and cancer with key publications in ageing research, including primary research papers, News & Views and a review article.

http://www.nature.com/nature/focus/senescence/index.html

 

Rodrigo

 

PS: In my post about entropy-syntropy and the work of Luigi Fantappie, I make a mistake in the conjugate of the verb To Admire. I write “I admired very much the work of Robert Rosen”. Of course what I want to mean was: I admire.