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Re: life as other than cellular/organismic



Judith,
 
You asked:
How do you suppose the first living systems reproduced? What is the "most primitive" mode of reproduction?
 
I am intrigued by the idea of Harold Morowitz, who proposed that perhaps pre-life evolution proceeded initially from the formation of primitive phospholipid bilayer vesicles, or "protocells", through chemical self-assembly. These closed environments happen to allow some selective transport of chemicals into and out of the vesicle which, combined with the otherwise isolated interior, became essentially the ecosystem (my phrasing, not his) for the initiation of proto-metabolic reaction pathways. 'Self-reproduction' would occur when vesicles stretched as their interior filled to some volume, at which point the vesicle walls would tear and reform as multiple smaller vesicles (think of a soap bubble expanding to where it breaks apart and forms smaller bubbles). Over evolutionary time, these vesicles and their internal metabolic organization would increase, eventually leading to all the forms of cellular life we see today. So in this scenario, "self-reproduction" (of a sort) actually evolutionarily precedes the origin of the first living cells.
 
I've not seen this idea mentioned elsewhere, but then again I'm not well-read on origin-of-life theories. It seems to me plausible in comparison to other o-o-l theories. I found this in Morowitz' book: Beginnings of Cellular Life: Metabolism Recapitulates Biogenesis (1992) Yale Univ. Press.
 
Regards,
Tim
 
 
 
-----Original Message-----
From: ROSEN Forum [mailto:***On Behalf Of Judith Rosen
Sent: Tuesday, April 13, 2004 5:57 PM
To: ***
Subject: Re: life as other than cellular/organismic

John M,

I have a few, interspersed, comments. But, first...I'm not sure what wording you are referring to here:

John M. wrote: beware of wording, "All" their genes come together from both parents, who, again came from 2 parents each, so not counting crpssfertilization in 10 generations 1022 donors would be invlved - not ONE commoner. Tis is a joke, but true.

The model 'ecosystem' is cut to practicality. Stan Salthen replied to my rambling that "there is no reproduction, because NONE of the involved TWO makes a perfect replica (unless cloned)" that
it is not the individual, that replicates, but the species.
 
In my research on mitochondrial DNA, I found several papers that dealt with the fact that a cloned animal isn't really an exact replica because the nucleus is the only part removed from the "host" egg cell, and is also the only part transplanted from the cell of the animal to be cloned. So the nuclear DNA is an exact replica, but the mitochondria are not. There is some curiosity as to whether this is what is causing the problems (health related and otherwise) in many cloned organisms.
 
I was fascinated by the statement that "it is not the individual that replicates, but the species." I tend to disagree, because it is individual changes that drive evolution, individual reproduction that "creates" a species.
 
John M. wrote: Here I ask: "what is the species"? we have to establish a pattern with allowances, like "a dog" either a chihuahua or a Dane, so a species is also a limited, agreed-upon, cut model.
Unimaginably subtle are the ways of reductionism!

A "species" is, ultimately, an artificial label placing organisms in categories for the benefit of human beings (be they scientists, farmers, Noah...). I think it is just human nature to deal with the world via categories. Our brains seem to be pattern seekers. Any difference we perceive in the pattern of some category requires the creation of a new category. I agree that it's a reductionist way of approaching the world but it works extremely well in many situations.
 
Here's a few questions for the list: How do you suppose the first living systems reproduced? What is the "most primitive" mode of reproduction? At what point did "sexual reproduction" evolve-- i.e. do any species of single celled organisms exchange genetic material during reproduction? What is the possibility that the behavior of viruses became involved somehow in the genesis of sexual reproduction in early organisms?
 
Judith


----- Original Message -----
From: Judith Rosen
To: ***
Sent: Tuesday, April 13, 2004 10:59 AM
Subject: Re: life as other than cellular/organismic


This has been sitting in my drafts folder, awaiting some spare time:

> Dan Fiscus posted:
> '"The naive picture that a group of organisms got all their
> genes from a simple last common ancestor is breaking down,"
> says microbiologist Gary Olsen of the University of Illinois at
> Urbana-Champaign. In its place, the image of a sophisticated,
> global community is emerging, he says. "In the past two years,
> it feels like it's fallen together into a coherent picture." Rather
> than a last common ancestor, LUCA may have been a last
> common community.'

Ecosystems are slippery to define. For example; what are the similarities and the differences between the concepts of "context", "environment", "ecosystem", and "biosphere"? Secondly, when studying biological systems, one must necessarily employ a reductionist technique, even if only in the language with which to refer to ideas. Thus, a single organism may be one that has only a single cell or it may be one that has billions of cells. Let's say we want to study the single celled organism. If its evolutionary context was the interior of a multicellular organism's body, then that defines as the "ecosystem" something which would, under another context of study, also be definable a single living system.  It is well known that multicellular organisms have served as the "ecosystems" for a whole mini universe of organisms, some of them are parasitic, some are incidental, and some are "beneficial", even necessary--  which makes them a symbiotic/mutualistic organism. How does that happen...

It seems that there are several ways to look at this. One, perhaps, would be to say that as living systems evolved more complex organizations the notion of an ecosystem was "internalized"-- within the organization-- every bit as much as the other aspects of its context (as per the "anticipatory predictive model). On the other hand, perhaps it is the nature of complexity to create relationships within/inside and without/outside the organization of the complexity of a multicellular organism, itself. Those relationships resemble one another in certain ways. It's like those optical illusions where a drawing looks concave one minute, then seems to change and looks convex... It's really both at the same time, and neither.

The question I have is whether, before organisms existed, there was any way for non-living systems to interact in  an "ecosystem"-- in the biological sense of that word. My definition of ecosystem is such that the very "first" living system, by virtue of being a living system, created the first ecosystem. It seems a near-certainty, to me, that there were several "first living systems" popping up independently, all at once. From each system's "perspective", all around it was "ecosystem" and each living system exploited every functional opportunity that presented itself.

It has been postulated that mitochondria were initially a distinct living system, because they have their own genetic heritage, separate from the nuclear genetic heritage of each cell. The functional benefits to each "organism" made possible by co-existence conferred such advantages that it continued. If that's how it happened, perhaps that was the moment the first multicellular organism, in a sense, was created.

Judith